Poorly Soluble Drug Containing Microspheres With Improved Bioavailability And Method Of Preparing The Same

摘要

A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.

主权项

1. A method for preparing a poorly soluble drug containing microsphere, comprising
a) dissolving a water-soluble polymer carrier and a poorly soluble drug in water and an organic solvent to prepare a mixed solution; and b) spray drying the mixed solution,
wherein the mixed solution does not include a surfactant, the weight ratio of the organic solvent and water is 0.5:1 to 5:1, and the poorly soluble drug is selected from the group consisting of acyclovir, candesartan, eprosartan, fenofibrate, atorvastatin, lovastatin, megestrol, simvastatin, sirolimus, tacrolimus and a combination thereof.