NOVEL ANTIBODIES INHIBITING c-MET DIMERIZATION, AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide an antibody capable of inhibiting a dimerization of c-Met and its partner as well as of binding to c-Met as a medicament for prevention or therapeutic treatment of a cancer involving overexpression of human c-Met receptor or any condition of the diseases.SOLUTION: The anti c-Met antibody consists of a heavy chain comprising CDR-H1, CDR-H2, and CDR-H3 and a light chain comprising CDR-L1, CDR-L2, and CDR-L3, and the anti c-Met antibody or functional divalent fragment thereof has a specific amino acid sequence. A pharmaceutical composition comprises the antibody for producing a medicament for treating cancer. Or a diagnostic process and a kit comprising the antibody. The pharmaceutical composition comprises an antibody derived from mouse, chimera, or human, or a monoclonal antibody.