发明名称 |
SITE-SPECIFIC INDUCTION OF BIMOLECULAR QUADRUPLEX-DUPLEX HYBRIDS AND METHODS OF USING THE SAME |
摘要 |
A method for the generation of a G-quadruplex structure on a target nucleic acid sequence is presented. The approach combines the specificity of Watson-Crick base pair with the stability associated with a robust G-quadruplex scaffold. The induction of such bimolecular quadruplex-duplex hybrids can be applied within the antigene or antisense context for enhanced steric blockage to the transcriptional or translational machinery. In addition, such structures provide unique features for ligand design. This approach also allows the site-specific generation of G-quadruplex structures within nucleic acid nanoarchitectures. |
申请公布号 |
WO2014098773(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013SG00544 |
申请日期 |
2013.12.20 |
申请人 |
NANYANG TECHNOLOGICAL UNIVERSITY |
发明人 |
PHAN, ANH TUAN;LIM, KAH WAI |
分类号 |
C12N15/113;C07H21/00;C12Q1/68 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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地址 |
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