| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure: wherein: B1 is selected from the group consisting of an optionally substitutedan optionally substitutedan optionally substitutedan optionally substitutedan optionally substitutedand an optionally substituted R1 is selected from the group consisting of an optionally substituted C1-6 alkyl, an optionally substituted C2-6 alkenyl, an optionally substituted C2-6 alkynyl and an optionally substituted C3-6 cycloalkyl; each -------- is absent or a single bond, provided that both -------- are each absent or both -------- are each a single bond; when both -------- are each a single bond, then R2 is halo, N3, —OR7A or —N(R7BR7C), R4 is absent; R3 is O; and Rp iswherein Zp is O or S and Rp1 is selected from the group consisting of O−, OH, an —O-optionally substituted C1-6 alkyl.an optionally substituted N-linked amino acid and an optionally substituted N-linked amino acid ester derivative;
when both -------- are each absent, then Rp is absent; R2 is halo, N3, —OR7A or —N(R7BR7C); R3 is —OH or —OC(═O)R8; or R2 and R3 are each an oxygen atom which are linked together by a carbonyl group; and R4 is hydrogen or R5A is selected from the group consisting of O−, OH, an optionally substituted N-linked amino acid, an optionally substituted N-linked amino acid ester derivative, R5B is selected from the group consisting of O−, OH, an —O-optionally substituted aryl, an —O-optionally substituted heteroaryl, an —O-optionally substituted heterocyclyl, an optionally substituted N-linked amino acid, an optionally substituted N-linked amino acid ester derivative, R6A is an optionally substituted C1-6 alkyl or an optionally substituted C3-6 cycloalkyl; R6B and R6C are independently selected from the group consisting of hydrogen, an unsubstituted C1-6 alkyl, an unsubstituted C3-6 alkenyl, an unsubstituted C3-6 alkynyl and an unsubstituted C3-6 cycloalkyl; R6D is NHR6G; R6E is hydrogen, halogen or NHR6H; R6F is NHR6I, R6G is selected from the group consisting of hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C3-6 alkenyl, an optionally substituted C3-6 cycloalkyl, —C(═O)RA1 and —C(═O)ORA2; R6H is selected from the group consisting of hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C3-6 alkenyl, an optionally substituted C3-6 cycloalkyl, —C(═O)RA3 and —C(═O)ORA4; R6I is selected from the group consisting of hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C3-6 alkenyl, an optionally substituted C3-6 cycloalkyl, —C(═O)RA5 and —C(═O)ORA6; X1 is N or —CR6J, R6J is selected from the group consisting of hydrogen, halogen, an optionally substituted C1-6 alkyl, an optionally substituted C2-6 alkenyl or an optionally substituted C2-6 alkynyl; RA1, RA2, RA3, RA4, RA5 and RA6 are independently selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C6-10 aryl, heteroaryl, heterocyclyl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl) and heterocyclyl(C1-6 alkyl); R7A is hydrogen or —C(═O)R12; R7B and R7C are independently hydrogen or an optionally substituted C1-6 alkyl; R8 and R12 are independently an optionally substituted C1-6 alkyl or an optionally substituted C3-6 cycloalkyl; R9, R10 and R11 are independently absent or hydrogen; R8A, R9A, R11A, R12A, R8B, R9B, R11B, R12B, Rp2, Rp3, Rp5 and Rp6 are independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl and an optionally substituted aryl; R10A, R10B, R13A, R13B, Rp4 and Rp7 are independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl, an optionally substituted aryl, an optionally substituted —O—C1-24 alkyl, an optionally substituted —O-aryl, an optionally substituted —O-heteroaryl and an optionally substituted —O-monocyclic heterocyclyl; R14A, R14B, R15A, R15B, Rp8 and Rp9 are independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl and an optionally substituted aryl; n is 0 or 1; p, q, and r are independently 1 or 2; s, t and u are independently 3, 4 or 5; Z1, Z1A, Z1B and Zp1 are independently O or S; and provided that when R4 isand R5A is O− or OH, then R5B is O−, OH, oran optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester derivative; and
provided that the compound is not selected from the group consisting of:or a pharmaceutically acceptable salt of the foregoing. |
