SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS

摘要

Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

主权项

1. An analytical device, comprising:
a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; an optically resolvable molecular complex immobilized within a confined region and sufficiently proximal to the first surface to be illuminated by an evanescent field emanating from the optical waveguide when light is passed through said optical waveguide; and at least a first excitation radiation source optically coupled to the substrate to provide the evanescent field by passing excitation light into the optical waveguide.