| 发明名称 |
Stabilised Solid Compositions of Factor VII Polypeptides |
| 摘要 |
The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature. |
| 申请公布号 |
US2014178356(A1) |
申请公布日期 |
2014.06.26 |
| 申请号 |
US201414186145 |
申请日期 |
2014.02.21 |
| 申请人 |
Novo Nordisk HealthCare AG |
发明人 |
Jensen Michael Bech;Hansen Birthe Lykkegaard;Kornfelt Troels |
| 分类号 |
A61K47/34;A61K47/10;A61K47/18;A61K38/48 |
主分类号 |
A61K47/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a Factor VII polypeptide, and at least one stability agent selected from the group consisting of
a) a combination of an antioxidant and mannitol; b) a combination of methionine and a polyol; c) a combination of a saccharide and mannitol; d) a combination of sucrose and a polyol; and e) methionine,said composition having a moisture content of not more than about 3%. |
| 地址 |
Zurich CH |
