发明名称 |
HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF |
摘要 |
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker. |
申请公布号 |
WO2014100762(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013US77306 |
申请日期 |
2013.12.20 |
申请人 |
BIOLLIANCE C.V.;ABGENOMICS INTERNATIONAL INC. |
发明人 |
LIN, RONG-HWA;LIN, SHIH-YAO;HSIEH, YU-CHI;HUANG, CHIU-CHEN |
分类号 |
C07D417/14;A61K31/496;A61P35/00;C07D295/192;C07K17/06 |
主分类号 |
C07D417/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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