The application is directed to APJ receptor agonist analogs having increased stability relative to the wild type apelin-13 and methods of using the agonist analogs. The analogs can be used, inter alia, in cardiac disorders such as heart failure.
申请公布号
WO2014099984(A1)
申请公布日期
2014.06.26
申请号
WO2013US75773
申请日期
2013.12.17
申请人
AMGEN INC.
发明人
HOLDER, JERRY RYAN;SWAMINATH, GAYATHRI;MIRANDA, LESLIE P.;ARAL, JENNIFER;DOHERTY, ELIZABETH M.;NIXEY, THOMAS