| 发明名称 |
Means and Methods to Diagnose Liver Toxicity using Putrescine as Biomarker |
| 摘要 |
The present invention concerns means and methods for predicting the risk of a subject to suffer from liver damage. In particular, it pertains to a method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen comprising determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and comparing the determined amount to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. Also provided are devices for carrying out the aforementioned methods. |
| 申请公布号 |
US2014178358(A1) |
申请公布日期 |
2014.06.26 |
| 申请号 |
US201314135730 |
申请日期 |
2013.12.20 |
| 申请人 |
The United States of America as represented by the Secretary of Department of Health and Human Servi ;Metanomics Health GmbH |
发明人 |
Strigun Alexander;Leonhardt Lisette;Ahlbory-Dieker Dörthe;Pence Lisa M.;Beger Richard |
| 分类号 |
G01N33/49;G06F19/28 |
主分类号 |
G01N33/49 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen, comprising
(a) determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and (b) comparing the amount determined in step (a) to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. |
| 地址 |
Bethesda MD US |
