ANTIVIRAL COMPOUNDS

摘要

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

主权项

1. A compound of formula (I):
E1a-V1a—C(═O)—P1a—W1a—P1b—C(═O)—V1b-E1b  (I)wherein:
W1a isand W1a is optionally substituted with one or more halo, alkyl, haloalkyl, optionally substituted aryl, optionally substituted heterocycle, or cyano;
Y5 is —O—CH2—, —CH2—O—, —O—C(═O)—, or —C(═O)—O—; X5 is —CH2—CH2—, or —CH═CH—; P1a and P1b are each independently: V1a and V1b are each independently: provided that at least one of V1a and V1b is E1a and E1b are each independently —N(H)(alkoxycarbonyl), —N(H)(cycloalkylcarbonyl), or —N(H)(cycloalkyloxycarbonyl); or E1a-V1a taken together are R9a; or E1b-V1b taken together are R9b; and R9a and R9b are each independently: or a pharmaceutically acceptable salt or prodrug thereof.