Anti-Malarial Pharmaceutical Composition

摘要

The invention provides pharmaceutical compositions for the treatment and prophylaxis of malaria, comprising artemether and a medium chain triglyceride formulated for transmucosal sublingual, buccal or nasal delivery, especially by a spray. Also provided are delivery devices containing the compositions.

主权项

1. A method of preventing or treating malaria, said method comprising the administration to a patient in need thereof a therapeutically effective amount of a composition by the transmucosal sublingual, buccal or nasal route, said composition comprising:
artemether or arteether; and a pharmaceutically-acceptable excipient selected from the group consisting of:
medium chain length triglycerides;short chain triglycerides;omega-3-marine triglycerides; andfish oil, rich in omega-3-acids, wherein said composition is formulated for transmucosal, sublingual, buccal or nasal dosage.