发明名称 |
METHOD FOR SYNTHESIZING AND SCREENING LEAD COMPOUND AND REAGENT TESTING KIT |
摘要 |
A method for synthesizing and screening a lead compound, comprising the following steps: (1) retrieving raw materials: retrieving an i-number of synthetic blocks and an (i+2)-number of single-stranded DNA fragments; (2) synthesizing a compound by using a combinatorial chemistry method, acquiring a library of a single-stranded DNA-marked compound; (3) screening: screening the library of the DNA-marked compound; and, (4) sequencing: retrieving the DNA-marked compound screened in step (3), and sequencing the DNA on the DNA-marked compound, where the synthesis blocks and reaction mechanism of the compound can be determined on the basis of the DNA sequencing. Also disclosed are a synthesis and screening reagent testing kit for the lead compound and a combinatorial chemistry library. |
申请公布号 |
WO2014094620(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013CN89873 |
申请日期 |
2013.12.18 |
申请人 |
HITGEN LTD. |
发明人 |
LI, JIN;JIANG, YANG;CHEN, SHI;QU, QINGXI;WAN, JINQIAO;ZHONG, LINA;GE, XIAOHU;HUANG, QI |
分类号 |
C40B40/04;C40B20/04;C40B50/04;C40B70/00 |
主分类号 |
C40B40/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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