| 摘要 |
The invention relates to A substrate for detecting the activity of IDE, of formula F-P-Q
- wherein P represents a peptide comprising at least one cleavage site for Insulin Degrading Enzyme (IDE),
- wherein F represents a fluorescent dye which is attached to at least one amino acid residue of P,
- wherein Q represents a quencher substance being able to quench the fluorescent dye F, and being attached to at least one amino acid residue of P, and
- whereby F and Q are attached to amino acids residues on different sides of the cleavage site of P,
with the proviso that there is no cleavage site for Angiotensin Converting Enzyme (ACE) present in said peptide between the amino acids to which F and Q are attached. |
