发明名称 SUSBTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
摘要 The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
申请公布号 ZA201200285(B) 申请公布日期 2014.06.25
申请号 ZA20120000285 申请日期 2012.01.13
申请人 JANSSEN PHARMACEUTICALS INC;CELLZOME LIMITED 发明人 WU TONGFEI;ROMBOUTS FREDERIK JAN RITA;BERTHELOT DIDIER JEAN-CLAUDE;DE CLEYN MICHEL ANNA JOZEF;MINNE GARRETH BERLOND;VAN BRANDT SVEN FRANCISCUS ANNA;GIJSEN HENRICUS JACOBUS MARIA;BISCHOFF FRANCOIS PAUL;OEHLRICH DANIEL;PIETERS SERGE MARIA ALOYSIUS;VALTER ADRIANA INGRID;SURKYN MICHEL
分类号 A61K;A61P;C07D 主分类号 A61K
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