| 发明名称 |
PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM |
| 摘要 |
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. |
| 申请公布号 |
ZA201302900(B) |
申请公布日期 |
2014.06.25 |
| 申请号 |
ZA20130002900 |
申请日期 |
2013.04.22 |
| 申请人 |
ARROWHEAD RESEARCH CORP |
发明人 |
ROZEMA DAVID B;LEWIS DAVID L;WAKEFIELD DARREN H;KITAS ERIC A;HADWIGER PHILIPP;WOLFF JON A;ROEHL INGO;MOHR PETER;HOFFMANN TORSTEN;JAHN-HOFMANN KERSTIN;MUELLER HANS MARTIN;OTT GUENTHER;BLOKHIN ANDREI V;BENSON JONATHAN D;CARLSON JEFFREY C |
| 分类号 |
A61K;A61P |
主分类号 |
A61K |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
