METHOD FOR THE PRODUCTION OF CELLULASES BY A FILAMENTOUS FUNGUS ADAPTED TO A FERMENTER HAVING A LOW VOLUMETRIC OXYGEN TRANSFER COEFFICIENT KLA

摘要

The present invention concerns a process for the production of cellulases using a strain of a filamentous fungus in a stirred, aerated bioreactor, comprising at least two growth steps: the first growth step in the presence of at least one carbonaceous growth substrate in batch phase with a concentration of carbonaceous growth substrate in the range 10 to 80 g/L; a second step for growth and production in the presence of at least one inducer carbonaceous substrate in fed batch phase in the presence of a limiting flow of carbon source in the range 50 to 140 mg per gram of cells per hour.