发明名称 |
METHOD AND DEVICE FOR ANALYSING MOLECULAR INTERACTIONS, AND USES THEREOF |
摘要 |
<p>The invention relates to a method for analysing an interaction between a first molecule and a second molecule bonded to a particle, including the following steps: contacting the first molecule with the second molecule bonded to the particle under conditions enabling the interaction thereof; applying a predetermined liquid flow to the particle bonded to the second molecule; observing a movement of the particle bonded to the second molecule caused by the applied flow; analysing the interaction according to the movement observed and the applied flow, the particle having a greater hydrodynamic resistance than the first and/or second molecule, and a mass Péclet number of greater than 1. The invention also relates to a device for analysing an interaction between a first molecule and at least one second molecule, as well as to the use of the method or of the device in screening a candidate molecule for developing a drug.</p> |
申请公布号 |
EP2596351(B1) |
申请公布日期 |
2014.06.25 |
申请号 |
EP20110752276 |
申请日期 |
2011.07.21 |
申请人 |
ECOLE POLYTECHNIQUE / DGAR |
发明人 |
TURKCAN, SILVAN;ALLAIN, JEAN-MARC;ALEXANDROU, ANTIGONI |
分类号 |
G01N33/50;B01L3/00;G01N21/64;G01N33/543;G01N33/58 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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