| 发明名称 |
AMIDATION PROCESS FOR THE PREPARATION OF CATHEPSIN K INHIBITORS |
| 摘要 |
<p>This invention describes an amidation process whereby amino acids of the Formulae IIA or IIB can be activated and treated with an amine in the presence of a base to yield amides of the Formula (I), without loss of optical purity.</p> |
| 申请公布号 |
EP2144871(B1) |
申请公布日期 |
2014.06.25 |
| 申请号 |
EP20080733702 |
申请日期 |
2008.03.31 |
| 申请人 |
MERCK CANADA INC. |
发明人 |
O'SHEA, PAUL;GOSSELIN, FRANCIS |
| 分类号 |
C07C315/04;A61K31/277;A61P19/10;A61P35/04;C07B43/06;C07C317/32 |
主分类号 |
C07C315/04 |
| 代理机构 |
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