发明名称 |
Oral vaccine |
摘要 |
The present invention provides an oral vaccine against a bacterial infectious disease (e.g., typhoid fever, cholera, or dysentery). The oral vaccine of the present invention is a capsule formulation in which a transformed microorganism that expresses a flagellin antigen protein or that secretes a flagellin antigen protein out of the cell of the microorganism is encapsulated with an acid-resistant membrane. Examples of the microorganism include intestinal bacteria belonging to the genus Bifidobacterium, the genus Lactobacillus, the genus Lactococcus, and the like. The form of the capsule formulation may be any one of a seamless capsule formulation, a soft capsule formulation, and a hard capsule formulation. |
申请公布号 |
US8758760(B2) |
申请公布日期 |
2014.06.24 |
申请号 |
US200812531507 |
申请日期 |
2008.03.19 |
申请人 |
Morishita Jintan Co., Ltd. |
发明人 |
Shirakawa Toshiro;Kawabata Masato;Takata Tetsuo;Taniguchi Michiko;Okamoto Asako;Asada Masanori;Nakatsuji Masaaki |
分类号 |
A61K39/00;A61K39/38;C12N1/20 |
主分类号 |
A61K39/00 |
代理机构 |
Renner, Otto, Boisselle & Sklar, LLP |
代理人 |
Renner, Otto, Boisselle & Sklar, LLP |
主权项 |
1. An oral vaccine against a bacterial infectious disease, in the form of a capsule formulation, comprising: a capsule membrane and a transformed microorganism that expresses a flagellin antigen protein, wherein the capsule membrane is acid resistant, and the transformed microorganism is encapsulated with the capsule membrane, wherein the microorganism is at least one selected from microorganisms belonging to the group consisting of the genus Bifidobacterium, the genus Lactobacillus, the genus Lactococcus, the genus Pediococcus, the genus Streptococcus, the genus Enterococcus, the genus Leuconostoc, the genus Tetragenococcus, the genus Oenococcus, and the genus Weissella.
|
地址 |
Osaka JP |