HLA-A* 3303-restricted WT1 peptide and pharmaceutical composition comprising the same

摘要

Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid sequence is selected from the group consisting of Ala, Ile, Leu, Val, Phe, Tyr, Ser and Asp and an amino acid residue at position 9 in the amino acid sequence is Arg; a polynucleotide encoding the peptide; a pharmaceutical composition comprising the peptide; and a method for the induction of a WT1-specific CTL using the peptide.

主权项

1. An isolated peptide consisting of 9 contiguous amino acids from a WT1 protein, wherein the 9 contiguous amino acid sequence is Ser Asp Gln Leu Lys Arg His Gln Arg (SEQ ID No: 4).