Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination

摘要

Disclosed is a pharmaceutical composition comprising a pyrazine derivative represented by the general formula:;
[wherein R1 and R2 independently represent a hydrogen atom or a halogen atom; and R3 represents a hydrogen atom or an amino-protecting group] or a salt thereof and at least one neuraminidase inhibitor. The pharmaceutical composition is useful for a treatment including the treatment or prevention of influenza. Also disclosed is a method of using these components in combination. The method is useful for a treatment including the treatment or prevention of influenza.

主权项

1. A pharmaceutical composition for treating influenza virus infection, comprising (A) a pyrazine derivative represented by the following general formula or a salt thereof; and (B) a neuraminidase inhibitor selected from the group consisting oseltamivir, zanamivir, peramivir, and CS-8958: wherein R1 is a hydrogen atom, R2 is fluorine, and R3 is a hydrogen atom, and wherein (A) and (B) are in synergistic and effective amounts.