Compositions and methods of treatment for inflammatory diseases

摘要

Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.

主权项

1. A method of treating an inflammatory bowel disease in a mammal by reducing cytokine gene expression in colonic tissue of the mammal, the method comprising
administering to the mammal by rectal delivery to a colon of the mammal 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, at a dose of between 1 mg/kg to 100 mg/kg, and N-acetylcysteine or a pharmaceutically-acceptable salt thereof, at a dose of between 1 mg/kg to 100 mg/kg, whereby administration of the combination of 5-aminosalicylic acid, or a pharmaceutically-acceptable salt thereof, and N-acetylcysteine, or a pharmaceutically-acceptable salt thereof, causes reduced cytokine gene expression in colonic tissue of the mammal.