发明名称 |
Ophthalmic composition with hyaluronic acid and polymeric biguanide |
摘要 |
An ophthalmic composition comprising 0.5 ppm to 3 ppm of poly(hexamethylene biguanide), and 0.002 wt. % to 0.03 wt. % of hyaluronic acid. The weight ratio of hyaluronic acid to poly(hexamethylene biguanide) in the composition is from 45:1 to 120:1. The invention is also directed to a method of cleaning, disinfecting or packaging contact lenses with the composition, or to a method of rewetting contact lenses with the composition. |
申请公布号 |
US8759321(B2) |
申请公布日期 |
2014.06.24 |
申请号 |
US200812109599 |
申请日期 |
2008.04.25 |
申请人 |
Bausch & Lomb Incorporated |
发明人 |
Burke Susan E.;Venkastesh Srini |
分类号 |
A61L12/14 |
主分类号 |
A61L12/14 |
代理机构 |
|
代理人 |
Vo Toan P.;Polyn Denis A. |
主权项 |
1. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in a multi-purpose lens care solution for at least two hours, the lens care solution comprising:
0.8 ppm to 2 ppm of poly(hexamethylene biguanide); 0.002 wt. % to 0.015 wt. % of hyaluronic acid, wherein the weight ratio of hyaluronic acid to poly(nexamethylene biguanide) in the composition is from 45:1 to 120:1; and 0.5 ppm to 2 ppm of α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium Chloride, wherein the lens care solution maintains disinfecting ability against each of S. aureus, P. aeruginosa, S. marcescens, C. albicans and F. solani, for a storage time period of up to and including four months at 30° C., in accordance with FDA-Premarket Notification 510(k) Guidance Document for contact lens care products.
|
地址 |
Rochester NY US |