发明名称 |
Inhibition of dynamin related protein 1 to promote cell death |
摘要 |
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i) Drp1 disruption-induced mitochondrial hyperfusion is functionally linked to the cell cycle regulation apparatus, so that Drp1 inhibition results in a disruption of the cell cycle and DNA aberrancies; (ii) inhibition of both Drp1 and ATR are synthetic lethal causing increased DNA damage and apoptotic cell death; and (iii) even in resistant cell lines, Drp1 inhibitor (e.g., mdivi-1) together with a second antiproliferative agent (e.g., cisplatin or carboplatin) act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies. |
申请公布号 |
US8759097(B2) |
申请公布日期 |
2014.06.24 |
申请号 |
US201213450345 |
申请日期 |
2012.04.18 |
申请人 |
University of Pittsburgh—of the Commonwealth System of Higher Eduction |
发明人 |
Qian Wei;Van Houten Bennett |
分类号 |
A61K31/517;A61P35/00;A61K38/38;C12N5/09 |
主分类号 |
A61K31/517 |
代理机构 |
Baker Botts, LLP |
代理人 |
Baker Botts, LLP |
主权项 |
1. A method for reducing cancer cell proliferation or promoting cancer cell death by administering, to a cancer cell, an effective amount of
|
地址 |
Pittsburgh PA US |