Long-acting coagulation factors and methods of producing same

摘要

Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

主权项

1. A CTP-modified Factor IX (FIX) polypeptide consisting of a FIX polypeptide and three chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said CTP-modified FIX polypeptide, wherein at least one CTP is optionally attached to said FIX polypeptide via a linker.