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1. A compound of formula I:or a stereoisomer, salt, hydrate, solvate, deuterated analogue, or crystalline form thereof, wherein
R1 is n-alkyl, branched alkyl, cycloalkyl, alkaryl, phenyl or naphthyl, where the phenyl or naphthyl is optionally substituted with at least one of F, Cl, Br, I, OH, OR′, SH, SR′, NH2, NHR′, NR′2, NHR′2+, NR′3+, C1-C6 alkyl, halogenated C1-C6 alkyl, halogenated C2-C6 alkenyl, C2-C6 alkynyl, halogenated C2-C6 alkynyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, CO2H, CO2R′, CONH2, CONHR′, CONR′2, CH═CHCO2H, or CH═CHCO2R′; R2 is of H, optionally substituted alkyl, cyano, CH3, vinyl, O-alkyl, O—(C1-C6 alkyl), hydroxyl C1-C6 alkyl, fluoromethyl, azido, CH2CN, CH2N3, CH2NH2, CH2NHCH3, CH2N(CH3)2, optionally substituted ethynyl alkyne, or halogen; R3 is CH3, CH2F, CHF2, CF3, F, or CN; X is F, OCH3, halogen, NH2, or N3; Base is of formula b: wherein R4 and R5 are independently H, F, CI, Br, I, OH, OR′, SH, SR′, NH2, NHR′, NR′2, NHR′2+, NR′3+, heterocycle, C1-C6 alkyl, halogenated C1-C6 alkyl, C2-C6 alkenyl, halogenated C2-C6 alkenyl, C2-C6 alkynyl, halogenated C2-C6 alkynyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, CO2H, CO2R′, CONH2, CONHR′, CONR′2, CH═CHCO2H, or CH═CHCO2R′; and wherein R′ is an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted alkynyl, an optionally substituted alkenyl, an optionally substituted acyl, or an optionally substituted alkoxyalkyl, where for the instance of NR′2 or NHR′2+, each R′ is independent of one another or both R′ are joined to form a heterocycle comprising at least two carbon atoms, and where for the instance of NR′3+, each R′ is independent of one another or at least two R′ are joined to form a heterocycle comprising at least two carbon atom.
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