Methods and compositions for inhibition of innate immune responses and autoimmunity

摘要

The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.

主权项

1. A method of inhibiting a TLR7/8 dependent immune response in an individual, wherein the individual is a human, the method comprising administering to the individual a composition comprising an oligonucleotide, in an amount sufficient to inhibit the TLR7/8 dependent immune response in said individual, wherein the oligonucleotide comprises SEQ ID NO: 105 or an analog of SEQ ID NO: 105 at the 5′ end of the oligonucleotide, the oligonucleotide is less than 50 bases or base pairs and does not comprise a CG dinucleotide, and wherein in the analog of SEQ ID NO: 105 one or two principal bases other than TGC of SEQ ID NO: 105 are each replaced with a naturally or occurring base or a modified, non-naturally occurring base.