Fertilization modulation compounds and process for implementing them

摘要

This invention relates to fertilization modulation compounds and process for implementing them.

主权项

1. A method for treating sterility, or for promoting or improving fertilization, or for promoting or improving a viable embryogenesis comprising the steps of: treating a sample comprising spermatozoa in vitro with a therapeutically effective amount of a mammalian group X secreted phospholipase A2 (group X sPLA2) to target inefficient spermatozoa and trigger an early acrosome reaction on said inefficient spermatozoa in the absence of oocytes, and contacting said group X sPLA2-treated spermatozoa sample with an oocyte having zona pellucida, wherein said in vitro treatment of spermatozoa results in enrichment of efficient spermatozoa and improved fertilization.