Robust pellet

摘要

Compositions and methods for making robust pellets that contain a high percentage, by weight, of active drug agent, and which also contain additional components that enhance the absorption and solubility of the active drug agent within the gastrointestinal tract (GI tract) without diminishing the robust nature of the pellet, are disclosed.

主权项

1. A pharmaceutical pellet comprising a granulated mixture, wherein the granulated mixture comprises at least one active ingredient drug component, at least one pharmaceutically acceptable absorption enhancing agent, wherein said at least one pharmaceutically acceptable absorption enhancing agent is selected from the group consisting of: non ionic surfactants, hydrophilic surfactants, hydrophobic surfactants, short chain fatty acids, long chain fatty acids, short chain triglycerides, and long chain triglycerides, and at least one pharmaceutically acceptable solubility enhancing agent, wherein said at least one pharmaceutically acceptable solubility enhancing agent is selected from the group consisting of: Methyl-2 Pyrrolidone, diethylene glycol monoethyl ether, and pharmaceutically accepted alcohols; wherein said at least one active ingredient drug component comprises at least one beta lactam penicillin and constitutes at least 50% W/W of said pharmaceutical pellet, wherein said at least one pharmaceutically acceptable absorption enhancing agent constitutes 2 to 10% W/W of said pharmaceutical pellet; wherein said at least one pharmaceutically acceptable solubility enhancing agent is a solvent for said at least one active ingredient drug component.