Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages

摘要

Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.

主权项

1. A polymer having the formula: wherein: A are poly(hydroxyacid) or poly(hydroxy-alkanoate) blocks; B are blocks of a biologically compatible polymer; X is a linking moiety; Y is a dihydric moiety; and n is an integer between 2 and 700; wherein the linking moiety is derived from at least one of, or any combination of, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, brassylic acid, dodecane-1,12-dicarboxylic acid, tridecane-1,13-dicarboxylic acid, thapsic acid, fumaric acid, maleic acid, and 1,3-acetonedicarboxylic acid; and wherein the biologically compatible polymer is poly(L-lysine)-graft-co-poly(ethylene glycol).