| 发明名称 | Subcutaneous paliperidone composition | ||
| 摘要 | The present invention relates to pharmaceutical composition for subcutaneous injection comprising a paliperidone compound wherein the composition releases the paliperidone with an immediate onset of action and continuously for at least 3 weeks, and wherein the composition has a pharmacokinetic profile in vivo with substantially no burst release of the paliperidone. The compositions are useful as medicaments for the treatment of psychotic disorders and diseases. | ||
| 申请公布号 | US8758780(B2) | 申请公布日期 | 2014.06.24 |
| 申请号 | US201013500623 | 申请日期 | 2010.10.06 |
| 申请人 | Ascendis Pharma AS | 发明人 | Sprogøe Kennett;Hersel Ulrich;Rau Harald;Maitro Guillaume;Wegge Thomas |
| 分类号 | A61K9/00 | 主分类号 | A61K9/00 |
| 代理机构 | Frommer Lawrence & Haug LLP | 代理人 | Frommer Lawrence & Haug LLP |
| 主权项 | 1. A pharmaceutical composition for subcutaneous injection comprising: a paliperidone compound; wherein the composition, after subcutaneous injection, releases the paliperidone with an immediate onset of action and continuously for at least 3 weeks; wherein the composition has a pharmacokinetic profile in vivo with substantially no burst release of the paliperidone; and wherein the paliperidone compound is covalently linked in a depot. | ||
| 地址 | Hellerup DK | ||