| 摘要 |
The present application provides for a compound of Formula I,;
or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent. |
| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt, wherein, X1 is selected from the group consisting of —C(O)—O—, —S(O)—, and —S(O2)—; X2 is selected from the group consisting of —O—, —NR6—C(O)—NR6—, —OC(O)NR6—, —NR6—, and —NR6C(O)O—; L is selected from the group consisting of a covalent bond, alkylene, and —CHR7—; R1 is selected from the group consisting of aryl, heteroaryl, arylalkyl, and heteroarylalkyl; each R2 is independently selected from the group consisting of H, alkyl, arylalkyl, heterocyclylalkyl, and cycloalkylalkyl wherein at least one R2 is arylalkyl; R3 is selected from the group consisting of heterocyclyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R4 and R5 are each independently selected from the group consisting of H, alkyl, cycloalkyl, heterocyclyl, cycloalkylalkyl, arylalkyl, and heterocyclylalkyl; each R6 is independently selected from the group consisting of H, alkyl, and cycloalkyl; and R7 is selected from the group consisting of H, alkyl, substituted alkyl, and heterocyclylalkyl; wherein each aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, and heteroarylalkyl of R1, R2, R3, R4, R5, R6 and R7 is unsubstituted or substituted.
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