Process of making polyhydroxyalkanoate medical textiles

摘要

Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.

主权项

1. A method of making a medical textile from a fiber comprising P4HB polymer, comprising quenching the fiber following extrusion at a temperature that is greater than the glass transition temperature of the polymer, orienting the fiber at a temperature above the polymer's glass transition temperature, allowing the polymer time to crystallize, and then drawing the polymer to yield a fiber with a tensile strength greater than 126 MPa.