发明名称 |
<i>N</i>-(5S,6S,9R)-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-ctclohepta[b]Pyridin-9-yl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-carboxylate salt |
摘要 |
Disclosed is a hemisulfate salt of Compound (I):;
and crystalline forms of the hemisulfate salt. Also disclosed are methods of using the hemisulfate salt of Compound (I) as a CGRP receptor antagonist, and pharmaceutical compositions comprising the hemisulfate salt of Compound (I). The hemisulfate salt of Compound (I) is useful in treating, preventing, or ameliorating disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD). |
申请公布号 |
US8759372(B2) |
申请公布日期 |
2014.06.24 |
申请号 |
US201313775528 |
申请日期 |
2013.02.25 |
申请人 |
Bristol-Myers Squibb Company |
发明人 |
Roberts Daniel Richard;Schartman Richard Raymond;Wei Chenkou |
分类号 |
C07D401/14;A61K31/444 |
主分类号 |
C07D401/14 |
代理机构 |
|
代理人 |
Epperson James |
主权项 |
1. A hemisulfate salt of Compound (I):
|
地址 |
Princeton NJ US |