| 发明名称 | Method for producing phenoxypyridine derivative | ||
| 摘要 | A method for producing a compound or a salt thereof represented by a formula (I), comprising reacting a compound or a salt thereof represented by a formula (II) and an aniline derivative represented by a formula (III) in water or a mixed solvent of water and an organic solvent in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and substantially in the absence of a base is disclosed,; wherein R1 is a 4-[3-(dimethylamino)azetidin-1-yl]piperidin-1-yl group, a 4-(4-methylpiperazin-1-yl)piperidin-1-yl group, a 3-hydroxyazetidin-1-yl group or a methyl(1-methylpiperidin-4-yl)amino group, R2, R3, R4 and R5 may be the same or different and are each a hydrogen atom or a fluorine atom, and R6 is a hydrogen atom or a halogen atom. | ||
| 申请公布号 | US8759530(B2) | 申请公布日期 | 2014.06.24 |
| 申请号 | US201213983891 | 申请日期 | 2012.03.27 |
| 申请人 | Eisai R&D Management Co., Ltd. | 发明人 | Takahashi Masabumi |
| 分类号 | C07D213/72 | 主分类号 | C07D213/72 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method for producing a compound or a salt thereof represented by a formula (I) wherein R1 is a 4-[3-(dimethylamino)azetidin-1-yl]piperidin-1-yl group, a 4-(4-methylpiperazin-1-yl)piperidin-1-yl group, a 3-hydroxyazetidin-1-yl group or a methyl(1-methylpiperidin-4-yl)amino group, R2, R3, R4 and R5 may be the same or different and are each a hydrogen atom or a fluorine atom, and R6 is a hydrogen atom or a halogen atom, comprising reacting a compound or a salt thereof represented by a formula (II) and an aniline derivative represented by a formula (III) in water or a mixed solvent of water and an organic solvent in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and substantially in the absence of a base. | ||
| 地址 | Tokyo JP | ||