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1. A compound of the formula Iwherein
either X is N and Y is CH, or X is CH and Y is N; Ar1 is selected from the group consisting of:
phenylene, pyridinylene and pyrimidinylene,wherein each of the beforementioned groups may be substituted with a substituent RA; RA is selected from the group consisting of:
H, F, Cl, Br, I, CN, OH, —NO2, C1-4-alkyl, C2-4-alkenyl, C1-4-alkyl-O—, C1-4-alkyl-C(═O)—, H2N—, H2N—C(═O)—, H2N—S(═O)2—, HO—C(═O)—, C1-4-alkyl-O—C(═O)—, phenyl and phenyl-C1-3-alkyl,
wherein in each NH2-group, one or both hydrogen atoms may independently be replaced by C1-4-alkyl; R1 is selected from the group consisting of:
OH, C1-4-alkyl-O—, C3-7-cycloalkyl-O—, C3-7-cycloalkyl-C1-3-alkyl-O—, H2N—, (C1-4-alkyl)NH—, (C1-4-alkyl)2N—, C3-7-cycloalkyl-NH—, C3-7-cycloalkyl-N(C1-4-alkyl)-, C1-4-alkyl-C(═O)—, C1-4-alkyl-S(═O)2-, HO—C(═O)—, C1-4-alkyl-O —C(═O)—, H2N—C(═O)—, (C1-4-alkyl)HN—C(═O)— and (C1-4-alkyl)2N—C(═O)—,
wherein each alkyl or cycloalkyl may be optionally substituted with one or more substituents selected from F and OH; Ar2 is selected from the group consisting of:
phenylene and a 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 heteroatoms selected from N, O, or S, R2 is selected from the group consisting of: H and C1-alkyl; R3 is selected from the group consisting of: H and methyl; R4 is selected from the group consisting of:
H, C1-4-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl, phenyl, and phenyl-C1-3-alkyl,
wherein each alkyl and cycloalkyl may be optionally substituted with one or more groups independently selected from the group consisting of: F, Cl, Br, CN, OH and —O—(C1-4-alkyl), andwherein each phenyl group may be optionally substituted with one or more substituents L; or R3 and R4 may be connected with each other and together with the N-atom to which they are attached form a group selected from the group consisting of:
azetidinyl, pyrrolidinyl, piperidinyl and azepanyl,
wherein in each of these groups one or two CH2-groups may be independently replaced by N, O, S, C(═O) or SO2, and/orwherein each of these groups may be substituted by one or more C1-4-alkyl; and L is selected from the group consisting of:
F, Cl, Br, CN, OH, C1-alkyl-, C1-4-alkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(═O)2-, H2N—, (C1-4-alkyl)NH—, (C1-4-alkyl)2N— and heterocyclyl,wherein each alkyl may be optionally substituted with one or more F-atoms and/ or with a substituent selected from OH, C1-3-alkyl-O— and CN; andwherein two substituents L attached to an aryl or heteroaryl group may be linked to each other and form a C2-5-alkylene bridging group in which 1 or 2 —CH2-groups may be replaced by a group independently of each other selected from O, S, NH and N(C1-4-alkyl)-, wherein the C2-5-alkylene bridging group is optionally be substituted by 1 or 2 C1-3-alkyl groups; or a pharmaceutically acceptable salt thereof.
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