发明名称 Heteroarylpiperidine and -piperazine derivatives as fungicides
摘要 Heteroarylpiperidine and -piperazine derivatives of the formula (I); in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).
申请公布号 US8759527(B2) 申请公布日期 2014.06.24
申请号 US201113216033 申请日期 2011.08.23
申请人 Bayer Cropscience AG 发明人 Tsuchiya Tomoki;Wasnaire Pierre;Hoffmann Sebastian;Cristau Pierre;Seitz Thomas;Kluth Joachim;Hillebrand Stefan;Benting Jürgen;Portz Daniela;Wachendorff-Neumann Ulrike
分类号 C07D417/14;A61K31/4535 主分类号 C07D417/14
代理机构 Miles & Stockbridge, PC 代理人 Miles & Stockbridge, PC
主权项 1. A compound of formula (I) and/or a salt, metal complex and/or N-oxides of a compound of the formula (I), wherein A is pyrazol-1-yl which may contain up to two substituents, where the substituents are each independently selected from the following list: substituents on carbon:halogen, cyano, hydroxyl, nitro, —NR3R4, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkenyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphonyl, C1-C4-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, C1-C6-alkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkylcarbonyloxy or phenyl, substituents on nitrogen:C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C10-cycloalkyl-C1-C6-alkyl, C1-C6-haloalkylcarbonyl, phenyl, benzyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylsulphonyl, phenylsulphonyl, —C(C═O)H, or C1-C6-alkylcarbonyl, RG1 is the same or different and is independently hydrogen, halogen, hydroxyl, thiol, nitro, cyan, —C(C═O)H, —C(C═O)OH, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, hydroxyalkyl, formylalkyl, alkoxyalkyl, alkylcarbonylalkyl, alkylcycloalkyl, alkoxy, alkylcycloalkylalkyl, alkylthio, aloalkylthio, alkynylthio, alkenyloxy, alkynyloxy, haloalkoxy, alkoxyalkoxy, alkylcarbonyloxy, haloalkylcarbonyloxy, cycloalkylcarbonylamino, alkylsulphonylamino, haloalkylsulphonylamino, phenylsulphonylamino, cycloalkylalkyl, halocycloalkylalkyl, cycloalkylcycloalkyl, alkoxycarbonyloxy, alkylcarbonylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyloxy, —C(C═O)NR3R4 or —NR3R4, R3 and R4 are the same or different and are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, benzyl or phenyl, L1 is C(RL11)2, RL11 is the same or different and is independently hydrogen, halogen, hydroxyl, cyano, —C(C═O)H, —C(C═O)OH, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, haloalkylthio, haloalkoxy, alkylcarbonyloxy, alkylcarbonylamino, alkylcarbonylthio, alkylsulphonyl, haloalkylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, trialkylsilyloxy, —NR3R4 or —C(C═O)NR3R4, or the two RL11 radicals, together with the carbon atom to which they are bonded, form a cyclopropyl ring, or the two RL11 radicals are ═CH2, ═COR3, ═NOR3 or ═CHN(R9)2, R9 is alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, benzyl or phenyl, Y is sulphur or oxygen, X is carbon, R2 is hydrogen, R10 is oxo, alkyl, alkenyl, haloalkyl, alkoxy, halogen, cyano or hydroxyl, p is 0 or 1, G is where the bond identified by “v” is bonded directly to X and where the bond identified by “w” is bonded directly to Q, Q is where the bond is identified by “*” is bonded directly to G or L2, and where the bond identified by “#” is bonded directly to L2 or G, or where the bond identified by “*” is bonded directly to L2, and the bond identified by “#” is at the same time bonded directly to G, R5 is the same or different and is independently: bonded to carbon of Q:hydrogen, oxo, halogen, cyano, hydroxyl, nitro, —CHO, —C(C═O)OH, —C(C═O)NH2, —C(C═O)NR3R4, —NR3R4, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylcycloalkyl, halocycloalkylalkyl, alkylcycloalkylalkyl, cycloalkenyl, halocycloalkenyl, alkoxyalkyl, haloalkoxyalkyl, cycloalkoxyalkyl, alkoxyalkoxyalkyl, alkylthioalkyl, formylalkyl, alkylcarbonylalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, alkylaminoalkyl, dialkylaminoalkyl, haloalkylaminoalkyl, cycloalkylaminoalkyl, alkylcarbonyl, haloalkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, cycloalkylaminocarbonyl, hydroxyalkyl, alkoxy, haloalkoxy, cycloalkoxy, halocycloalkoxy, cycloalkylalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkoxyalkoxy, alkylcarbonyloxy, haloalkylcarbonyloxy, cycloalkylcarbonyloxy, alkylcarbonylalkoxy, alkylthio, haloalkylthio, cycloalkylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl, cycloalkylsulphonyl, trialkylsilyl, alkylsulphonylamino, haloalkylsulphonylamino,bonded to nitrogen of Q:hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, phenyl, benzyl, alkylsulphonyl, —C(C═O)H, alkoxycarbonyl or alkylcarbonyl, L2 is a direct bond, m is 0, 1 or 2, R20 is hydrogen, alkyl or haloalkyl, R1 is phenyl which is substituted at least once by a substituent Z4 and may otherwise be unsubstituted or substituted, where the substituents are each independently selected from Z4 and optionally from Z1, Z1 is hydrogen, halogen, hydroxyl, —SH, nitro, cyano, C(═O)H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, cycloalkenyl, halocycloalkyl, halocycloalkenyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, cycloalkoxyalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylaminoalkyl, haloalkylaminoalkyl, cycloalkylaminoalkyl, dialkylaminoalkyl, alkylsulphonylalkyl, alkylcycloalkyl, alkoxy, alkylcycloalkylalkyl, halocycloalkoxy, alkylthio, haloalkylthio, cycloalkylthio, alkenyloxy, alkynyloxy, haloalkoxy, haloalkenyloxy, haloalkynyloxy, cycloalkoxy, alkoxyalkoxy, cycloalkylalkoxy, alkylcarbonyloxy, haloalkylcarbonyloxy, cycloalkylcarbonyloxy, cycloalkylamino, alkylsulphonylamino, haloalkylsulphonylamino, cycloalkylalkyl, halocycloalkylalkyl, cycloalkylcycloalkyl, alkoxyalkoxyalkyl, alkylcarbonylalkoxy, cycloalkylaminocarbonyl, cycloalkylalkoxycarbonyl, alkylcarbonylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl, cycloalkylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkoxycarbonyl, trialkylsilyl, —NR3R4, —C(C═O)NR3R4 or -L3Z3, L3 is a direct bond, —CH2—, —C(C═O)—, sulphur, oxygen, —C(C═O)O—, —C(C═O)NH—, —OC(═O)— or —NHC(═O)—, or L3 is —NR20—, —C(═S)—, —S(O)m—, —CHR20—, —CHR20—CHR20—, —CR20═CR20, —OCHR20—, —CHR20O—, Z3 is a phenyl radical, naphthalenyl radical or a 5- or 6-membered heteroaryl radical, each of which may contain 0, 1, 2 or 3 substituents, where the substituents are each independently selected from the following list: substituents on carbon: halogen, cyano, nitro, hydroxyl, amino, —SH, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkoxyalkyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkoxy, haloalkoxy, cycloalkoxy, halocycloalkoxy, alkenyloxy, alkynyloxy, alkoxyalkoxy, alkylamino, dialkylamino, alkylthio, haloalkylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl, trisilylalkyl or phenyl,substituents on nitrogen: hydrogen, —C(C═O)H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylsulphonyl, haloalkylsulphonyl, cycloalkylsulphonyl, phenylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, cycloalkoxycarbonyl, —C(C═O)NR3R4, phenyl or benzyl, Z4 is alkylsulphonyloxy.
地址 Monheim DE