Inhibitors of cholesterol ester transfer protein

摘要

The invention relates to novel oxazolidinones their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering cholesterol ester transfer protein inhibitors.

主权项

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
Each of Y1, Y2, Y3, Y4, Y5, Y6, Y7 and Y8 is independently selected from hydrogen and deuterium; R1 is CD3; each of R2 and R3 is independently selected from CH3, CH2D, CHD2, and CD3; R4 is selected from H, CH3, CH2D, CHD2, and CD3; R5 is selected from H and F; and the stereochemistry at * is either (R) or (S).