发明名称 |
ISOTOP-PRODUKTIONSFREMGANGSMÅDE |
摘要 |
<p>The present invention relates to a method for the generation of 223 Ra of pharmaceutically tolerable purity comprising:
i) preparing a generator mixture comprising 227 Ac, 227 Th and 223 Ra in a first aqueous solution comprising a first mineral acid;
ii) loading said generator mixture onto a DGA separation medium (e.g. resin);
iii) eluting said 223 Ra from said DGA separation medium using a second mineral acid in a second aqueous solution to give an eluted 223 Ra solution; and
iv) stripping the DGA separation medium of said 227 Ac and 227 Th by flowing a third mineral acid in a third aqueous solution through the DGA separation medium in a reversed direction; The invention further relates to high purity radium-223 formed or formable by such a method as well as pharmaceutical compositions comprising such radium-223 of pharmaceutical purity.</p> |
申请公布号 |
DK2564397(T3) |
申请公布日期 |
2014.06.23 |
申请号 |
DK20110719187T |
申请日期 |
2011.04.29 |
申请人 |
ALGETA ASA |
发明人 |
KARLSON, JAN ROGER;BÿRRETZEN, PEER |
分类号 |
G21G1/00;A61K51/12 |
主分类号 |
G21G1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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