| 摘要 |
FIELD: medicine.SUBSTANCE: topical gel composition for treating erythema or a related symptom contains brimonidine 0.4 wt % to 0.6 wt %, preferentially in the form of brimonidine tartrate, a gelatinising agent, and at least one polyol. The topical application of the gel composition on the skin involved in erythema or having a manifestation of the related symptom has an effect on a serum or plasma profile of brimonidine with an average Cmax approximately 54±28 pcg/ml or less and an average AUCapproximately 568±277 pcg·h/ml or less.EFFECT: safe and effective treatment of erythema causing no inadequate drug-related side effects.19 cl, 3 dwg, 5 tbl, 3 ex |
