METHOD OF PHOTODYNAMIC THERAPY OF TUMOURS

摘要

FIELD: medicine.SUBSTANCE: method involves using a photosensitiser (PS) pre-detected in the tumour by its fluorescence that is followed by tumour irradiation by light emission at a wave length in the spectral range of PS peak absorption. The PS is presented by the genetically coded protein KillerRed by providing its tumour expression by gene insertion into the tumour cells. The tumour is exposed to the light emission at energy density of 180-270 J/cm3 times every second day or 7 times daily. The protein KillerRed is preferentially localised either in mytochondria and nuclei, or in nuclei.EFFECT: method provides high-selectivity PS effect on the tumour, reduced toxic load on the intact organs and tissues, the absence of PS redistribution in the tumour, with no need for the constant radiation control.2 cl, 6 dwg, 11 ex