发明名称 |
ANTIGEN-BINDING MOLECULE FOR PROMOTING LOSS OF ANTIGENS |
摘要 |
The present inventors created antigen-binding molecules containing an antigen-binding domain and an Fc³-receptor-binding domain, wherein the molecules have human-FcRn-binding activity in an acidic pH range condition, the antigen-binding domain changes the antigen-binding activity of the antigen-binding molecules depending on the ion-concentration condition, and the Fc³ receptor-binding domain has higher binding activity to the Fc³ receptor in a neutral pH range condition than an Fc region of a native human IgG in which the sugar chain bound at position 297 (EU numbering) is a fucose-containing sugar chain. |
申请公布号 |
KR20140076593(A) |
申请公布日期 |
2014.06.20 |
申请号 |
KR20147011132 |
申请日期 |
2012.09.28 |
申请人 |
CHUGAI SEIYAKU KABUSHIKIKAISHA |
发明人 |
IGAWA TOMOYUKI;MAEDA ATSUHIKO;HARAYA KENTA;IWAYANAGI YUKI;TACHIBANA TATSUHIKO |
分类号 |
A61K39/395;A61P29/00;C07K14/47;C12P21/02 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|