| 发明名称 |
METHODS OF GENERATING HYPER INOS EXPRESSING CELLS AND USES THEREOF |
| 摘要 |
A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell. |
| 申请公布号 |
US2014170165(A1) |
申请公布日期 |
2014.06.19 |
| 申请号 |
US201313780503 |
申请日期 |
2013.02.28 |
| 申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
Lu Kurt Q.;Cooper Kevin D. |
| 分类号 |
A61K39/395;A61K31/4439;A61K38/00 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of generating a hyper iNOS expressing cell comprising: administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell.
|
| 地址 |
Cleveland OH US |
