PRESERVATION OF THE NEUROMUSCULAR JUNCTION (NMJ) AFTER TRAUMATIC NERVE INJURY

摘要

The invention relates to treatment and/or prevention of nerve injury. In one embodiment, the present invention provides a method of preserving the neuromuscular junction (NMJ) in an individual by administering a therapeutically effective dosage of a composition comprising an inhibitor of Wnt3a, and an inhibitor of MMP3 to the individual. In another embodiment, the present invention provides a method of stabilizing NMJ after nerve injury by inhibiting the WNT and beta-catenin signaling pathway and preserving agrin.

主权项

1. A method of treating nerve injury in an individual, comprising:
providing a composition comprising one or more of the following: agrin, an inhibitor of the matrix metalloproteinase 3 (MMP3) signaling pathway, an inhibitor of the WNT signaling pathway, and an inhibitor of the beta-catenin signaling pathway; and administering a therapeutically effective dosage of the composition to the individual.