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1. A method for identifying candidate compounds for limiting development of and/or treating diabetes, comprising
a) contacting a first population of insulin secreting cells with an amount of apolipoprotein CIII (ApoCIII) effective to increase density and/or conductivity of Cav1 channels, in the presence of one or more test compounds; b) contacting a second population of insulin secreting cells with an amount of ApoCIII effective to increase density and/or conductivity of Cav1 channels, in the presence of the one or more test compounds, and further contacting the second population of insulin secreting cells with a molecule that inhibits scavenger receptor class B type I (SRBI) expression or activity, and c) identifying positive test compounds that inhibit the ApoCIII-induced increase in density and/or conductivity of Cav1 channels in the first population of insulin secreting cells to a greater degree than in the second population of insulin secreting cells as candidate compounds for limiting development of and/or treating diabetes.
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