| 摘要 |
<p>Peroral nanoscale cyclophosphamide particles and a preparation method thereof. Silicon dioxide aerogel is used as a carrier. For the silicon dioxide aerogel, the porosity is 95 to 99%, the pore diameter is 10 to 50 nm, the specific surface area is 200 to 1000 m2/g, the density is 3 to 300 kg/m3, the gel particle diameter of the formation network is 1 to 50 nm, and the cyclophosphamide is adsorbed in the hole of the silicon dioxide aerogel to form cyclophosphamide particles with the diameter less than 100 nm. The preparation method is as follows: first dissolving cyclophosphamide in anhydrous ethanol, adding the silicon dioxide aerogel, drying after full adsorption, then adding purified water, feeding into an emulsifying machine for emulsification, homogenizing through a high pressure homogenizer, and then drying.</p> |
