STABLE GENES IN COMPARATIVE TRANSCRIPTOMICS

摘要

Various embodiments perform stable gene analysis of transcriptome sequencing data. In one embodiment, a plurality of datasets each including transcriptome sequencing data are received by a processor. Each of the plurality of datasets includes a plurality of genes and a respective ranking value for each of the plurality of genes. A plurality of rank normalized input datasets is generated based on assigning, for each of the plurality of datasets, a rank to each of the plurality of genes. One or more longest increasing subsequence (LIS) of ranks are identified between each pair of the plurality of rank normalized input datasets. A set of stable genes from the plurality of genes is identified based on each of the one or more LIS of ranks across the plurality of rank normalized input datasets.

主权项

1. A computer implemented method for performing stable gene analysis of transcriptome sequencing data, the computer implemented method comprising:
obtaining, by a processor, a plurality of datasets each comprising transcriptome sequencing data, wherein each of the plurality of datasets comprises a plurality of genes and a respective ranking value associated with each of the plurality of genes; obtaining a plurality of rank normalized input datasets based on assigning, for each of the plurality of datasets, a rank to each of the plurality of genes; identifying, between each pair of the plurality of rank normalized input datasets, one or more longest increasing subsequence of ranks; and identifying, based on each of the one or more longest increasing subsequence of ranks of each of the plurality of rank normalized input datasets, a set of stable genes from the plurality of genes.