| 摘要 |
PROBLEM TO BE SOLVED: To provide P2X3 and/or P2X2/3 antagonists usable for treatment of diseases associated with P2X purinergic receptors, and more particularly to genitourinary, pain, inflammatory, gastrointestinal and respiratory diseases, conditions and disorders.SOLUTION: This invention provides oxazolone and pyrrolidinone-substituted arylamide compounds represented by the formula I, and methods of making and using compounds for treating diseases associated with P2Xand/or P2Xreceptor antagonists, in which X, Y, R, R, R, R, R, Rand Rare specific groups. |
