FUSION PROTEINS FORMING TRIMERS

摘要

The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein. The fusion proteins, the nucleic acid, and the cell are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein.

主权项

1. A fusion protein comprising
(i) a collectin family trimerization domain consisting of the amino acid residues 217-375, 218-375, 219-375, 220-375, 221-375, 222-375, 223-375, 224-375, 225-375 of SEQ ID NO: 21, optionally further consisting of an amino acid substitution at residue 355; (ii) a linker element; and (iii) an effector polypeptide selected from the group consisting of a single chain antibody, an antigen binding fragment of a single chain antibody, or an antigen binding fragment of an antibody;
wherein said linker element has 25 or less amino acids.