PEPTIDE FOR INHIBITING ACTIVITY OF T CELL

摘要

The present invention relates to peptide inhibiting T cell activity. In phosphoinositide-dependent kinase 1 (PDK1) including a first amino acid sequence of the sequence listing, 513th amino acid, Threonine is substituted with phosphomimic or phosphorylation-disabled amino acid, and the peptide consists of 8 to 50 sequential amino acids including the substituted 513th amino acid. Existing PDK1 regulators are mostly synthetic compounds regulating the activity of PDK1 kinase, and the synthetic compounds have a possibility of causing side effects by widely regulating the PDK1 functions. The peptide in the present invention specifically regulates T cell and NF-κB activities induced by PDK1, thereby being unlikely to cause the side effects.